The next release of Radiant CMS will be a great one. The interface is definitely nicer and should make running multiple extensions much cleaner with the new navigation scheme.
One annoyance that's been in it for a long time is the lack of a tag reference on the Snippet and Layout screens where they are arguably most needed. I hope to get an update for that in the next release. Radius tags on Pages should be discouraged, in my opinion, for the sake of the end user's understanding of the system so it seems backwards that we'd have a reference on the Page edit screens and not in a place where it's most needed.
If there's something that you think is missing, or a bug that needs fixing, please go vote for it.